Collect. Czech. Chem. Commun.
1986, 51, 141-155
https://doi.org/10.1135/cccc19860141
6-Substituted and 2-chloro-6-substituted 10-piperazino-10,11-dihydrodibenzo[b,f]thiepins as potential antidepressants; Synthesis and pharmacology
Irena Červená, Jiří Holubek, Emil Svátek, Jiřina Metyšová, Martin Valchář, Antonín Dlabač, Stanislav Wildt and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
6-Substituted and 2-chloro-6-substituted 10-chloro-10,11-dihydrodibenzo[b,f]thiepins XIIIa - f were reacted with 1-(ethoxycarbonyl)piperazine and the carbamates IIIa - f obtained were hydrolyzed to the title compounds Ia -f. The new chlorides XIIIa - c were obtained from 2-(2-aryl-thiophenyl)acetic acids VIIIa - c via ketones XIa - c and alcohols XIIa - c. Reactions of the chlorides XIIIa and XIIIc with 1-methylpiperazine afforded compounds IIa and IIc. All compounds I are devoid of antireserpine and cataleptic activity; they are neither typical antidepressants nor neuroleptics.
